[1] viXra:1004.0021 [pdf] submitted on 8 Mar 2010
Authors: Sreepurna Malakar, Florentin Smarandache, Sukanto Bhattacharya
Comments: 12 pages
This short technical paper advocates a bootstrapping algorithm from which we can form a
statistically reliable opinion based on limited clinically observed data, regarding whether
an osteo-hyperplasia could actually be a case of Ewing's osteosarcoma. The basic
premise underlying our methodology is that a primary bone tumour, if it is indeed
Ewing's osteosarcoma, cannot increase in volume beyond some critical limit without
showing metastasis. We propose a statistical method to extrapolate such critical limit to
primary tumour volume. Our model does not involve any physiological variables but
rather is entirely based on time series observations of increase in primary tumour volume
from the point of initial detection to the actual detection of metastases.
Category: Quantitative Biology